August 17, 2004Circulation
Prevalent Low-Frequency Oscillation of Heart Rate
Key result
Prevalent low-frequency oscillation ≥0.1 Hz was a powerful independent predictor of all-cause mortality in postinfarction patients (RR 4.6; 95% CI 2.2-9.3; P=0.00003).
Why the study?
Does prevalent low-frequency oscillation (PLF) index >=0.1 Hz predict mortality in postinfarction patients?
Population
Postinfarction patients from the placebo population of the European Myocardial Infarction Amiodarone Trial…
Design
Cohort, blindly validated in the ATRAMI trial
Authors
Discussion
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Implication
PLF may aid post-MI stratification on Holter; leaves open prospective validation before clinical adoption.
Study Design
Type
Cohort
Multicenter
Yes
Structured PICO
Does prevalent low-frequency oscillation (PLF) index >=0.1 Hz predict mortality in postinfarction patients?
P
Population
Postinfarction patients from the placebo arm of the EMIAT trial and the ATRAMI trial, evaluated for mortality risk using 24-hour Holter recordings.
E
Exposure
Prevalent low-frequency oscillation (PLF) index >=0.1 Hz derived from 24-hour Holter recordings
O
Outcome
All-cause mortality (in EMIAT) and cardiac mortality or resuscitated cardiac arrest (in ATRAMI)hard clinical
Main Result
Relative Risk: 4.6 (95% CI 2.2–9.3)
p-value: p=0.00003
Prevalent low-frequency oscillation (PLF) derived from 24-hour Holter recordings is a strong, independent predictor of mortality in post-myocardial infarction patients.
Cite This Study
Wichterle et al. (2004) conducted a cohort in Myocardial infarction. Prevalent low-frequency oscillation (PLF) ≥0.1 Hz vs. PLF <0.1 Hz was evaluated on All-cause mortality (RR 4.6, 95% CI 2.2-9.3, p=0.00003). Prevalent low-frequency oscillation ≥0.1 Hz was a powerful independent predictor of all-cause mortality in postinfarction patients (RR 4.6; 95% CI 2.2-9.3; P=0.00003).