Key result
Prior VT linked to ~6-fold higher sudden death risk in Ebstein anomaly.
Why the study?
Ebstein anomaly presents with both right and left heart abnormalities, but predictors of sudden death have not been described.
What are the incidence and risk factors for sudden death in patients with Ebstein anomaly?
Population
968 patients with Ebstein anomaly evaluated at a high-volume institution over 4 decades
Design
Retrospective cohort study
Authors
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Prior VT warrants enhanced monitoring in Ebstein anomaly; extends risk stratification but leaves open prospective validation.
Cohort (n=968)
No
What are the incidence and risk factors for sudden death in patients with Ebstein anomaly?
Hazard Ratio: 6.37
p-value: p=<0.001
Patients with Ebstein anomaly face a significant risk of sudden death, and identifying clinical predictors such as prior ventricular tachycardia, heart failure, and prior tricuspid valve surgery can aid in risk stratification for primary prevention ICD implantation.
Jost et al. (2017) conducted a cohort in Ebstein anomaly (n=968). Prior ventricular tachycardia vs. No prior ventricular tachycardia was evaluated on Sudden death (HR 6.37, p=<0.001). Prior ventricular tachycardia (HR 6.37, P<0.001), heart failure, and tricuspid valve surgery were strong multivariable predictors of sudden death in patients with Ebstein anomaly.
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