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July 1, 2026Scientific ReportsOpen Access

Comparison of serum irisin and leptin levels in obese and non-obese women with polycystic ovary syndrome

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Authors

YCYeliz ColakogluŞŞŞenol ŞentürkRecep Tayyip Erdoğan UniversityMAMedeni ArpaRecep Tayyip Erdoğan University

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Implication

Prospective case-control study compares metabolic biomarkers in women with and without PCOS, suggesting obesity influences outcomes.

Key Points

  • This study aims to investigate the relationship between serum irisin and leptin levels in obese and non-obese women with polycystic ovary syndrome (PCOS) compared to healthy controls.
  • Prospective case-control study involving 80 women: 40 with PCOS and 40 healthy controls.
  • Groups divided into obese and non-obese subgroups for analysis.
  • Serum levels of irisin and leptin were measured using ELISA kits.
  • Leptin levels were lower in women with PCOS compared to healthy controls.
  • Irisin levels were significantly lower in obese women, regardless of PCOS status (p < 0.05).
  • Leptin positively correlated with BMI, insulin levels, and insulin resistance; irisin negatively correlated with BMI and insulin resistance.

Cite This Study

Colakoglu et al. (2026) studied this question.

synapsesocial.com/papers/6a44ad765cd2549c8bc4304ehttps://doi.org/10.1038/s41598-026-58075-z
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Circulating levels of irisin and Meteorin-like protein in PCOS and its correlation with metabolic parameters2024 · 5 citations
  2. 2Determination of insulin resistance, adiponectin and leptin in overweight women with polycystic ovarian syndrome2025 · 1 citations
  3. 3Study the concentrations of Leptin, adiponectin and some parameters in women with polycystic ovaries syndrome2024
  4. 4Association between serum adipocyte factor level and insulin resistance in polycystic ovarian syndrome2011 · 20 citations
  5. 5Serum adiponectin and ghrelin in polycystic ovarian syndrome and its correlation with insulin resistance2022