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July 1, 2026Journal of Radiation Research and Applied SciencesOpen Access

The use of 3D contrast-enhanced ultrasound in assessing the technical success rate of thermal ablation for hepatocellular Carcinoma: A meta-analysis

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Authors

YZYuhui ZhangZLZheng LiQHQiang He

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Overview

Meta-analysis evaluates 3D-CEUS diagnostic accuracy for assessing hepatocellular carcinoma post-ablation, suggesting high effectiveness.

Key Points

  • Evaluate the diagnostic accuracy of 3D-CEUS in measuring technical success rates after thermal ablation for HCC.
  • Systematic literature search in multiple databases until April 30, 2026.
  • Independent data extraction and quality assessment using QUADAS-2 tool.
  • Bivariate generalized linear mixed model used to analyze sensitivity, specificity, and other diagnostic metrics.
  • Pooled sensitivity of 3D-CEUS was 0.85 (95% CI: 0.77–0.93), indicating strong detection capability.
  • Pooled specificity reached 0.97 (95% CI: 0.95–0.99), confirming high accuracy for ruling out inadequate ablation.
  • AUC was 0.971 (95% CI: 0.935–0.988), reflecting excellent overall diagnostic performance.

Cite This Study

Zhang et al. (2026) studied this question.

synapsesocial.com/papers/6a44add75cd2549c8bc433adhttps://doi.org/10.1016/j.jrras.2026.102551
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Ablation margin quantification after thermal ablation of malignant liver tumors: How to optimize the procedure? A systematic review of the available evidence2023 · 20 citations
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  3. 3Three-dimensional contrast-enhanced ultrasound fusion imaging predicts local tumor progression by evaluating ablative margin of radiofrequency ablation for hepatocellular carcinoma: a preliminary report2018 · 23 citations
  4. 4Intraprocedural contrast-enhanced ultrasound (CEUS) in liver percutaneous radiofrequency ablation: clinical impact and health technology assessment2014 · 138 citations