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September 16, 2025Frontiers in RadiologyOpen Access

Evaluation of the effectiveness of contrast-enhanced ultrasound in the diagnosis of early hepatocellular carcinoma: a systematic review

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Authors

AAAbdulaziz AlTaweelFJFaisal JoueidiAJAhmad Joueidi

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Overview

Systematic review reveals contrast-enhanced ultrasound can diagnose small HCC in cirrhotic patients, indicating high potential for early detection.

Key Points

  • Contrast-enhanced ultrasound effectively identifies small hepatocellular carcinoma lesions, improving early diagnosis and management.
  • The review included thirteen studies with 2016 patients, and found CEUS showed high concordance with CECT for lesions 2.1–3.0 cm.
  • Utilizing conventional ultrasonography alongside CEUS enhanced detection of HCC in patients with liver cirrhosis.
  • Standardization of protocols and validation in Western populations are vital to fully realize CEUS's clinical value.

Cite This Study

AlTaweel et al. (2025) studied this question.

synapsesocial.com/papers/68d4566231b076d99fa5b56fhttps://doi.org/10.3389/fradi.2025.1661522
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Diagnostic Accuracy of Contrast-Enhanced Ultrasound Compared with Contrast-Enhanced Computed Tomography in the Follow-Up of Hepatocellular Carcinoma Treated with Radiofrequency Ablation2025
  2. 2Clinical impact of CEUS on non-characterizable observations and observations with intermediate probability of malignancy on CT/MRI in patients at risk for HCC2024 · 12 citations
  3. 3The use of 3D contrast-enhanced ultrasound in assessing the technical success rate of thermal ablation for hepatocellular Carcinoma: A meta-analysis2026
  4. 4Accuracy of Contrast-Enhanced Ultrasound for Hepatocellular Carcinoma post Transcatheter Arterial Chemoembolization 2024 · 1 citations
  5. 5Updates on the Diagnostic Use of Ultrasonography Augmented With Perfluorobutane Contrast in Hepatocellular Carcinoma: A Meta-Analysis2024