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The study aimed to formulate floating microspheres of Cefuroxime axetil for enhanced gastric retention and controlled release.

July 1, 2026Open Access

Formulation and Development of Floating Microspheres of Cefuroxime Axetil

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Randomized trial develops floating microspheres for prolonged gastric retention, suggesting improved drug release.

The study aimed to formulate floating microspheres of Cefuroxime axetil for enhanced gastric retention and controlled release.
Floating microspheres were developed using HPMC and EC by solvent diffusion evaporation method.
Evaluations included percentage yield, drug entrapment efficiency, buoyancy, particle size, zeta potential, and in-vitro drug release.
The optimized formulation was identified based on maximum yield and efficiency measurements.
The optimized formulation (F3) achieved a percentage yield of 73.32%, drug entrapment efficiency of 75.56%, and buoyancy of 76.65%.
Particle size and zeta potential were determined to be 198.3 nm and -35.8 mV, respectively.
In-vitro drug release demonstrated sustained release over 12 hours, following zero-order kinetics (R²=0.958).

*1Kajal Singh, 2Dr. Arun Patel, 3Shailendra Patel (2026) studied this question.

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