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July 1, 2026Journal of Biochemical and Molecular Toxicology

MiR‐30a‐5p Suppresses the ERK Signaling Pathway by Targeting Vimentin to Inhibit the Migration and Epithelial–Mesenchymal Transition of Colorectal Cancer Cells

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Authors

FTFei TuFHFengyuan HeYZYu Zhang

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Overview

Functional assays demonstrate that miR-30a-5p inhibits migration and epithelial-mesenchymal transition in colorectal cancer, suggesting therapeutic potential.

Key Points

  • This research aims to clarify the role of miR-30a-5p in colorectal cancer metastasis and progression.
  • Analyzed GEO public datasets
  • Performed RT-qPCR to assess miR-30a-5p levels in CRC
  • Conducted functional assays to evaluate cell migration and EMT effects
  • miR-30a-5p was found to be downregulated in CRC
  • Overexpression of miR-30a-5p inhibited CRC cell migration and EMT
  • miR-30a-5p directly targets vimentin, reducing ERK signaling pathway activation

Cite This Study

Tu et al. (2026) studied this question.

synapsesocial.com/papers/6a44af055cd2549c8bc441e4https://doi.org/10.1002/jbt.71002
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1miR-30b-5p acts as a tumor suppressor microRNA in esophageal squamous cell carcinoma2019 · 44 citations
  2. 2<scp>miR</scp>‐30c‐5p inhibits esophageal squamous cell carcinoma progression by repressing the <scp>PI3K</scp>/<scp>AKT</scp> signaling pathway2024 · 1 citations
  3. 3MiR-19b-3p facilitates colorectal cancer metastasis by mediating the crosstalk between tumor-associated endothelial cells and malignant cells2026
  4. 4MicroRNA-345-3p expression inhibits colorectal cancer liver metastasis by targeting KHDRBS1 and TGF-β signaling pathway2026
  5. 5miR-30b-5p suppresses prostate cancer progression by targeting FLVCR1 through the cAMP/PKA/CREB pathway2026