What question did this study set out to answer?

The study aims to understand the dynamic changes in myeloid-derived suppressor cells (MDSCs) during multiple myeloma treatment and their association with treatment response.

July 1, 2026Clinical and Translational ScienceOpen Access

Circulating M‐ MDSC Expansion During Therapy Associates With Treatment Response in Multiple Myeloma: A Longitudinal Observational Study

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The study aims to understand the dynamic changes in myeloid-derived suppressor cells (MDSCs) during multiple myeloma treatment and their association with treatment response.
Measured M‐MDSCs and PMN‐MDSCs by flow cytometry in 99 newly diagnosed MM patients
Focused analysis on 78 patients treated with bortezomib-lenalidomide-dexamethasone (VRd)
Assessed changes in M‐MDSCs post-induction and after autologous stem cell transplantation (ASCT).
M‐MDSCs significantly expanded during VRd treatment (median Δ +0.98%, p < 0.0001) and normalized after ASCT.
Patients with ≤ partial response showed higher ΔM‐MDSCs compared to those with ≥ very good partial response (median +1.56% vs. +0.50%, p = 0.0083).
ΔM‐MDSCs did not predict suboptimal response after adjusting for R2‐ISS (OR 1.28 per 1% increase, p = 0.109).

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Implication

Longitudinal observational study reveals M‐MDSC changes correlate with treatment response in multiple myeloma patients, suggesting further investigation is needed.

Cite This Study

Yan et al. (2026) studied this question.

synapsesocial.com/papers/6a44af325cd2549c8bc444b4 https://doi.org/10.1111/cts.70660

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Implication

Longitudinal observational study reveals M‐MDSC changes correlate with treatment response in multiple myeloma patients, suggesting further investigation is needed.

Circulating M‐ MDSC Expansion During Therapy Associates With Treatment Response in Multiple Myeloma: A Longitudinal Observational Study

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Discussion

Implication

Cite This Study

Circulating M‐ MDSC Expansion During Therapy Associates With Treatment Response in Multiple Myeloma: A Longitudinal Observational Study

Key Points

Discussion

Implication

Cite This Study

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