Key result
A 48-year-old female with pre-existing coronary vasospasm successfully tolerated de novo 5-fluorouracil chemotherapy infusions with prophylactic administration of anti-spasm medications.
Why the study?
5-fluorouracil can cause severe cardiotoxic side effects such as coronary vasospasm and ventricular arrhythmias, and its administration is not typically reported in individuals with pre-existing coronary vasospasm.
Does prophylactic administration and optimization of anti-spasm medications allow safe administration of 5-fluorouracil in a patient with pre-existing coronary vasospasm?
Case Report (n=1)
No
Does prophylactic administration and optimization of anti-spasm medications allow safe administration of 5-fluorouracil in a patient with pre-existing coronary vasospasm?
Prophylactic administration and optimization of anti-spasm medications may allow for the safe administration of 5-fluorouracil in patients with pre-existing coronary vasospasm.
Supports cautious 5-FU use with prophylaxis in vasospastic angina; hypothesis-generating and requires prospective validation.
A 48-year-old female with metastatic colon adenocarcinoma and history of pre-existing coronary vasospasm with ventricular tachycardia (VT) successfully tolerated de novo 5-fluorouracil (5-FU) chemotherapy infusions with prophylactic administration and optimization of anti-spasm medications. 5-FU has been reported to produce severe cardiotoxic side effects, including coronary vasospasm, ventricular arrhythmias, and sudden cardiac death, and is not typically reported in individuals with pre-existing coronary vasospasm.
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Tai et al. (2022) conducted a case report in Metastatic colon adenocarcinoma and pre-existing coronary vasospasm (n=1). 5-fluorouracil (5-FU) infusion with prophylactic anti-spasm medications was evaluated on Tolerance of 5-FU infusion without severe cardiotoxic side effects. A 48-year-old female with pre-existing coronary vasospasm successfully tolerated de novo 5-fluorouracil chemotherapy infusions with prophylactic administration of anti-spasm medications.
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