Key result
Atrial pacing at the maximum ventricular follow rate prolonged the duration that repetitive ventricular responses could be elicited to 70 minutes, compared to 22 minutes in sinus rhythm.
Why the study?
Does atrial pacing at maximum ventricular follow rate affect the duration of electrically induced repetitive ventricular responses in digitalized dogs?
Population
Digitalized dogs (acetylstrophanthidin-induced ventricular tachycardia model)
Comparison
Atrial pacing at maximum ventricular follow rate vs Sinus rhythm
Design
Preclinical
Authors
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These dog-model results leave open heart-rate effects on digitalis-related arrhythmias in humans; clinical studies needed before any practice implications.
Does atrial pacing at maximum ventricular follow rate affect the duration of electrically induced repetitive ventricular responses in digitalized dogs?
Absolute Event Rate: 70% vs 22%
Heart rate acceleration prolongs the period during which repetitive ventricular responses can be elicited in digitalis intoxication, likely due to intracellular potassium loss.
Hagemeijer et al. (1970) studied Digitalis intoxication. Atrial pacing (heart rate acceleration) vs. Sinus rhythm was evaluated on Duration of elicitable repetitive ventricular response (RVR). Atrial pacing at the maximum ventricular follow rate prolonged the duration that repetitive ventricular responses could be elicited to 70 minutes, compared to 22 minutes in sinus rhythm.
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