Why the study?
Does digitalization with ouabain alter the diastolic threshold energy for repetitive ventricular response to electrical stimulation in an animal model?
Population
Animal model
Comparison
Ouabain administration combined with unipolar… vs Nondigitalized state (baseline)
Design
Preclinical
Authors
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May heighten arrhythmia risk during ouabain digitalization in animals; leaves open translation to human digitalis toxicity.
Does digitalization with ouabain alter the diastolic threshold energy for repetitive ventricular response to electrical stimulation in an animal model?
Digitalization with ouabain profoundly reduces the threshold for repetitive ventricular responses to electrical stimulation, predisposing to ventricular tachycardia as toxicity approaches.
Lown et al. (1967) studied this question.
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