Effects of Lidocaine, Disopyramide and Verapamil on the In Vivo Triggered Ventricular Arrhythmia in Digitalized Canine Heart

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Why the study?

Does lidocaine, disopyramide, or verapamil suppress triggered ventricular arrhythmias in a digitalized canine model?

Population

In vivo canine model of ventricular arrhythmias triggered by ventricular stimulation during administration…

Design

Preclinical

Authors

Discussion

Lidocaine and disopyramide merit testing in triggered arrhythmias; leaves open clinical translation from this canine model.

Does lidocaine, disopyramide, or verapamil suppress triggered ventricular arrhythmias in a digitalized canine model?

Population

In vivo canine model of ventricular arrhythmias triggered by ventricular stimulation during administration of low doses of ouabain

Intervention

Lidocaine (1 and 3 mg/kg, i.v.), disopyramide (0.3 and 1 mg/kg, i.v.), or verapamil (0.2 mg/kg, i.v.)

Outcome

Suppression of triggered ventricular ectopic beatssurrogate

Lidocaine and disopyramide, but not verapamil, suppress triggered ventricular arrhythmias in a digitalized canine model.

Akiyama et al. (1990) studied this question.

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