Key result
Graded lower body negative pressure at -50 mmHg reduced internal carotid artery blood flow from 411 to 311 ml/min (P=0.044), while vertebral artery blood flow remained unchanged (P=0.597).
Why the study?
Does graded lower body negative pressure alter blood flow differently in the internal carotid and vertebral arteries in humans?
Population
Humans
Comparison
Graded lower body negative pressure vs Baseline (pre-LBNP)
Authors
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Differential cerebrovascular responses during orthostasis warrant mechanistic studies; leaves open clinical relevance for orthostatic intolerance.
Does graded lower body negative pressure alter blood flow differently in the internal carotid and vertebral arteries in humans?
Absolute Event Rate: 311% vs 411%
p-value: p=0.006
Graded orthostatic stress reduces internal carotid artery blood flow but not vertebral artery blood flow, suggesting posterior cerebral circulation is preserved until severe orthostatic stress.
Ogoh et al. (2015) studied Orthostatic stress. Graded lower body negative pressure (LBNP) vs. Baseline (pre-LBNP) was evaluated on Blood flow in internal carotid artery (ICA) and vertebral artery (VA) (p=0.006). Graded lower body negative pressure at -50 mmHg reduced internal carotid artery blood flow from 411 to 311 ml/min (P=0.044), while vertebral artery blood flow remained unchanged (P=0.597).
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