Key result
Sympathetic activation produced graded decreases in tissue oxygenation and blood flow that were highly correlated in resting human forearm (r=0.80, P<0.0001) and rat hindlimb (r=0.93, P<0.0001).
Why the study?
Can near-infrared spectroscopy reliably assess sympathetic vasoconstriction by measuring tissue oxygenation compared to Doppler ultrasound in resting and exercising skeletal muscle?
Population
Conscious humans (n=13) and anesthetized rats (n=9)
Comparison
Near-infrared spectroscopy to measure tissue… vs Doppler ultrasound measurement of blood flow
Design
Preclinical
Authors
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May support NIRS-Doppler evaluation of sympathetic muscle perfusion; leaves open clinical translation in cardiovascular settings.
Can near-infrared spectroscopy reliably assess sympathetic vasoconstriction by measuring tissue oxygenation compared to Doppler ultrasound in resting and exercising skeletal muscle?
Effect estimate: r = 0.80
p-value: p=< 0.0001
Near-infrared spectroscopy can reliably assess sympathetic vasoconstriction in resting and exercising skeletal muscle by measuring changes in tissue oxygenation.
Fadel et al. (2004) studied this question. Sympathetic activation (lower body negative pressure or electrical stimulation) vs. Resting state was evaluated on Correlation between decreases in tissue oxygenation and blood flow during sympathetic activation in resting muscle (r = 0.80, p=< 0.0001). Sympathetic activation produced graded decreases in tissue oxygenation and blood flow that were highly correlated in resting human forearm (r=0.80, P<0.0001) and rat hindlimb (r=0.93, P<0.0001).
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