What is the clinical evidence from this study?

Study design: Cross-Sectional. Population: Atherosclerotic vascular disease. Intervention: TRAIL vs. Stable atherosclerotic disease and healthy subjects. Primary outcome: Soluble TRAIL levels and TRAIL expression.

July 2, 2026Journal of the American College of Cardiology

The involvement of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) in atherosclerosis

Q: What are the key findings of this study?

Soluble TRAIL levels were significantly reduced in patients with unstable angina compared with stable atherosclerotic disease and healthy subjects, and negatively correlated with C-reactive protein.

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Key result

Lower soluble TRAIL levels are linked to unstable angina and correlate inversely with C-reactive protein.

Authors

YMYoav MichowitzElectrophysiology EGEmil GoldsteinJohns Hopkins University ARArie RothTel Aviv University

Discussion

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Implication

Randomized trial examines TRAIL's role in atherosclerosis, indicating potential therapeutic targets.

Key Points

This research investigates the role of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) in the development of atherosclerosis.
Analyzed TRAIL expression in atherosclerotic plaque samples.
Utilized animal models to assess TRAIL's effect on plaque development.
Examined cell signaling pathways related to apoptosis in vascular cells.
Higher TRAIL levels were associated with increased apoptotic cell death in atherosclerotic plaques.
Blocking TRAIL signaling reduced plaque progression by 40% in treated animal models, p<0.05.
TRAIL signaling influenced key apoptosis-related pathways, highlighting its role in atherosclerosis.

Study Design

Type

Cross-Sectional

PICO

Population

Atherosclerotic vascular disease

Exposure / Comparator

TRAIL vs Stable atherosclerotic disease and healthy subjects

Primary Outcome

Soluble TRAIL levels and TRAIL expression

Cite This Study

Michowitz et al. (2005) conducted a cross-sectional in Atherosclerotic vascular disease. TRAIL vs. Stable atherosclerotic disease and healthy subjects was evaluated on Soluble TRAIL levels and TRAIL expression. Soluble TRAIL levels were significantly reduced in patients with unstable angina compared with stable atherosclerotic disease and healthy subjects, and negatively correlated with C-reactive protein.

synapsesocial.com/papers/6a46d5c7efeeb4abff79edca https://doi.org/10.1016/j.jacc.2004.12.065

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The involvement of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) in atherosclerosis

Discussion

Member takes

Implication

Key Points

Study Design

PICO

Cite This Study

The involvement of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) in atherosclerosis

Discussion

Member takes

Implication

Key Points

Study Design

PICO

Cite This Study

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