Key result
Diabetes mellitus and pregnancy-induced diabetes were associated with a significant increase in ADP-induced platelet biosynthesis of thromboxane A2 compared to normal controls (P<0.001).
Why the study?
Does diabetes increase the biosynthesis of thromboxane A2 by platelets in response to ADP?
Population
n=88 human subjects, including 30 normal volunteers, 26 diabetic subjects, 18 non-diabetic pregnant females…
Comparison
In vitro incubation of washed human platelets… vs Platelets from non-diabetic controls and…
Design
Preclinical
Authors
Loading...
Suggests heightened platelet reactivity in diabetes; leaves open causal role in complications and need for clinical validation.
Cross-Sectional (n=88)
Does diabetes increase the biosynthesis of thromboxane A2 by platelets in response to ADP?
p-value: p=<0.001
Platelets from diabetic patients exhibit increased biosynthesis of pro-aggregating thromboxane A2 in response to ADP, suggesting a potential mechanism for the vascular complications associated with diabetes.
Ziboh et al. (1979) conducted a cross-sectional in Diabetes mellitus (n=88). Diabetes mellitus vs. Normal controls was evaluated on Platelet biosynthesis of thromboxane A2 in response to ADP (p=<0.001). Diabetes mellitus and pregnancy-induced diabetes were associated with a significant increase in ADP-induced platelet biosynthesis of thromboxane A2 compared to normal controls (P<0.001).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: