Why the study?
Do platelets from patients with diabetes mellitus exhibit increased synthesis of prostaglandin-E-like material and aggregation compared to controls?
Population
17 subjects with diabetes mellitus and 21 matched controls (n=38)
Comparison
In vitro exposure of platelet-rich plasma to… vs Platelet-rich plasma from matched controls…
Design
Case-control
Authors
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May heighten thrombotic risk in diabetes; leaves open whether prostaglandin inhibition improves outcomes.
Do platelets from patients with diabetes mellitus exhibit increased synthesis of prostaglandin-E-like material and aggregation compared to controls?
Platelets from diabetic patients show increased prostaglandin synthetase activity, which may contribute to the heightened platelet aggregation and thrombotic risk associated with diabetes.
Halushka et al. (1977) studied this question.
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