Key result
Elevated NT-proBNP levels were independently associated with poor 90-day functional outcomes in patients with acute ischemic stroke (adjusted OR 1.029).
Why the study?
To investigate the impact of NT-proBNP on CTP infarct core volume and poor 90-day functional outcomes in acute ischemic stroke.
Are elevated NT-proBNP levels associated with larger CTP infarct core volume and poor 90-day functional outcomes in patients with acute ischemic stroke?
Cohort (n=403)
No
Are elevated NT-proBNP levels associated with larger CTP infarct core volume and poor 90-day functional outcomes in patients with acute ischemic stroke?
Odds Ratio: 1.029 (95% CI 1.003–1.055)
p-value: p=0.027
NT-proBNP was associated with larger ischemic volumes and worse outcomes; hypothesis-generating for prognostic utility in acute stroke.
OBJECTIVE: To investigate the impact of N-terminal pro-B-type natriuretic peptide (NT-proBNP) on CTP infarct core volume and poor 90-day functional outcomes in acute ischemic stroke (AIS). METHODS: A total of 403 hospitalized patients with AIS in the Stroke Center of the First Hospital Affiliated to Soochow University were enrolled from March 2018 to January 2021. The association between NT-proBNP and clinical outcomes in acute ischemic patients was assessed by logistic regression and adjusted for confounding factors. Also, subgroup analyses were conducted based on treatment decisions. RESULTS: NT-proBNP was positively correlated with CTP ischemic volume (p < 0.001), infarct core volume (p < 0.001), and ischemic penumbra volume (p < 0.001). Univariate analysis showed that the influence of NT-proBNP and functional outcomes were statistically significant in model 1 (p = 0.002). This phenomenon was persistent after adjusted for age, sex, and body mass index in model 2 (p = 0.011), adjusted for SBP, current smoking, family history of stroke, hypertension, and diabetes mellitus in model 3 (p < 0.001), and adjusted for TnI, D-dimer, PLT, Cr, TC, TG, HDL-C, treatment decisions, and NIHSS score in model 4 (p = 0.027). A high NT-proBNP was associated with a high 90-days mRS score among the total population, IV rt-PA, and standardized treatment groups, but not in IV rt-PA + EVT, EVT, and EVT/IV rt-PA + EVT groups. CONCLUSION: Elevated NT-proBNP levels reveal large CTP infarct core volume and poor 90-day functional outcome in AIS. NT-pro BNP is an independent risk factor for functional outcomes.
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Shen et al. (2022) conducted a cohort in Acute ischemic stroke (n=403). Elevated NT-proBNP levels vs. Lower NT-proBNP levels was evaluated on Poor 90-day functional outcome (mRS score 3-6) (OR 1.029, 95% CI 1.003-1.055, p=0.027). Elevated NT-proBNP levels were independently associated with poor 90-day functional outcomes in patients with acute ischemic stroke (adjusted OR 1.029).