Key result
In acute ischemic stroke patients without cardiac comorbidities, high NT-proBNP levels were independently associated with a significantly increased risk of poor functional outcomes at 90 days (OR 2.46).
Why the study?
The study aimed to evaluate the prognostic value of NT-proBNP for predicting adverse outcomes in patients with anterior and posterior circulation acute ischemic stroke, specifically those without pre-existing cardiac comorbidities.
Does elevated NT-proBNP predict poor functional outcomes at 90 days in patients with acute ischemic stroke without cardiac disease?
Population
821 patients with acute ischemic stroke within 7 days of symptom onset
Comparison
Medium and high vs low NT-proBNP levels
Design
Single-center prospective observational study
Follow-up
90 days
Authors
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Elevated NT-proBNP was associated with poor 90-day outcomes and END in non-cardiac ACI; leaves open its added value for risk stratification.
Observational (n=821)
No
Does elevated NT-proBNP predict poor functional outcomes at 90 days in patients with acute ischemic stroke without cardiac disease?
Odds Ratio: 2.46 (95% CI 1.3–4.67)
p-value: p=0.006
Elevated NT-proBNP levels are an independent predictor of poor 90-day functional outcomes in acute ischemic stroke patients, particularly those with anterior circulation infarction and no pre-existing cardiac disease.
Liu et al. (2025) conducted an observational in Acute ischemic stroke (n=821). Elevated NT-proBNP levels vs. Low NT-proBNP levels was evaluated on Poor functional outcome (mRS 3-6) at 90 days (OR 2.46, 95% CI 1.30-4.67, p=0.006). In acute ischemic stroke patients without cardiac comorbidities, high NT-proBNP levels were independently associated with a significantly increased risk of poor functional outcomes at 90 days (OR 2.46).
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