Key result
Neonatal lupus erythematosus presents a clinical spectrum of cardiac abnormalities in fetuses and infants, most commonly congenital atrioventricular block, alongside other cardiovascular manifestations.
Neonatal lupus presents with a wide spectrum of cardiovascular manifestations beyond congenital AV block, necessitating comprehensive cardiac evaluation in affected fetuses and infants.
May warrant expanded cardiac evaluation in NLE; leaves open prospective data on rarer manifestations.
'Neonatal' lupus erythematosus (NLE) describes a clinical spectrum of cardiac and non-cardiac abnormalities observed in neonates and foetuses whose mothers have the auto-antibodies anti-SSA/Ro (anti-Ro) and anti-SSB/La (anti-La). Of the cardiac abnormalities, congenital AVB is the most common cardiovascular abnormality found in affected foetuses and infants. Many other cardiovascular manifestations of NLE have been more recently recognized including atrial and ventricular arrhythmias and other conduction abnormalities, myocarditis, cardiomyopathy often with endocardiofibroelastosis and structural heart disease, particularly valvar lesions. In this report, the spectrum of cardiovascular manifestations observed in foetuses and infants with NLE are reviewed and the pathogenesis, diagnosis and clinical outcomes are briefly discussed.
No takes yet. Share an insight, caveat, or question.
Hornberger et al. (2010) conducted a review in Neonatal lupus erythematosus (NLE). Maternal auto-antibodies anti-SSA/Ro and anti-SSB/La was evaluated. Neonatal lupus erythematosus presents a clinical spectrum of cardiac abnormalities in fetuses and infants, most commonly congenital atrioventricular block, alongside other cardiovascular manifestations.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: