Key result
Anti-SSA antibodies link to cardiac presentation, which occurs in ~57% of neonatal lupus cases.
Why the study?
The clinical features, autoantibodies, and outcomes of neonatal lupus erythematosus were explored to better characterize the disease manifestations and prognosis.
Observational
No
Anti-SSA and anti-SSB antibodies are significantly associated with cardiac and cutaneous manifestations in neonatal lupus erythematosus, which generally has a good prognosis except for the potential of persistent congenital heart block.
Anti-SSA positivity may flag higher cardiac risk in NLE; leaves open prospective validation before guiding screening or management.
Objectives: To explore the clinical features, autoantibodies, and outcome of neonatal lupus erythematosus (NLE). Methods: We retrospectively reviewed all NLE cases from January 2012 to May 2019 that occurred in our department. Results: Cutaneous, cardiac, hematologic, and hepatobiliary manifestations were found in 36.7%, 56.7%, 56.7%, and 30.0% of cases, respectively. The presence of anti-SSA antibodies was correlated with cardiac presentation (p = .026) and the presence of anti-SSB antibodies was associated with cutaneous lesions (p = .015). During the follow-up, one patient with a third-degree atrioventricular block died, and a third-degree AV block persists in a child without a pacemaker at 4-years of age. No other manifestations of NLE were observed after the age of 12 months. Conclusions: Anti-SSA and anti-SSB are associated with cardiac and cutaneous manifestations in NLE. Most children with NLE have excellent outcomes with symptom resolution by one year. Complete congenital heart block may persist.
No takes yet. Share an insight, caveat, or question.
Xiaofeng Yang (2020) conducted an observational in Neonatal lupus erythematosus. Anti-SSA and anti-SSB antibodies was evaluated on Clinical features, autoantibodies, and outcome. In neonatal lupus erythematosus, cardiac and hematologic manifestations were most common (56.7% each), with anti-SSA antibodies associated with cardiac presentation (p=0.026).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: