Key result
Childhood ALL survivors had lower e' septal velocities than controls (11.0 vs 12.6 cm/s, P<0.001); reduced VO2 max occurred more in anthracycline-treated vs naive survivors (56% vs 17%, P<0.001).
Why the study?
Does previous anthracycline exposure impair left ventricular diastolic function and exercise capacity in long-term adult survivors of childhood acute lymphoblastic leukemia?
Population
138 adult survivors of childhood acute lymphoblastic leukemia, median 23.4 years after diagnosis, and 138…
Comparison
Previous anthracycline exposure vs Matched controls and anthracycline-naïve survivors
Design
Cross-sectional
Follow-up
median 23.4 years after diagnosis
Authors
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Supports diastolic surveillance in anthracycline-exposed ALL survivors; leaves open causal links and intervention effects.
Cross-Sectional (n=276)
Does previous anthracycline exposure impair left ventricular diastolic function and exercise capacity in long-term adult survivors of childhood acute lymphoblastic leukemia?
Absolute Event Rate: 11% vs 12.6%
p-value: p=< 0.001
Long-term adult survivors of childhood ALL with previous anthracycline exposure have an increased risk of impaired LV diastolic function and reduced exercise capacity.
Christiansen et al. (2015) conducted a cross-sectional in childhood acute lymphoblastic leukemia (ALL) (n=276). Childhood ALL survivorship and anthracycline exposure vs. Matched controls and anthracycline-naive survivors was evaluated on early diastolic mitral annular velocities (e') septal (p=< 0.001). Childhood ALL survivors had lower e' septal velocities than controls (11.0 vs 12.6 cm/s, P<0.001); reduced VO2 max occurred more in anthracycline-treated vs naive survivors (56% vs 17%, P<0.001).
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