Key result
RV PET/CT uptake reflects pressure overload from PE and RV strain rather than cardiac malignancy.
Right ventricular hypermetabolic activity on PET/CT in patients with pulmonary embolism represents a physiologic response to pressure overload rather than malignancy.
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Prevents misdiagnosis of cardiac malignancy in PE; leaves open prospective validation of RV uptake as physiologic response.
Pulmonary embolism can be seen in patients with malignancy. Positron Emission Tomography/ Computerized Tomography (PET/CT) can show hypermetabolic activity in the right ventricle in patients with pulmonary embolism and right ventricular strain, representing a physiologic response to pressure overload rather than cardiac malignancy.
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Greeley et al. (2026) studied this question. Right ventricular uptake on PET/CT indicates a physiologic response to pressure overload from pulmonary embolism and right ventricular strain rather than cardiac malignancy.
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