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July 1, 2026

Characterisation of the Novel HLA-A*02:1295N Allele by Sequencing-Based Typing.

Thibault Pajot Isabelle Top Julie Demaret Vincent Elsermans

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Key Points

This research aims to characterize the HLA-A*02:1295N allele and its differences from the known HLA-A*02:02:01:01 allele.
Utilized sequencing-based typing to analyze the allele.
Focused on the nucleotide sequence in codon 157.
Compared results with HLA-A*02:02:01:01 allele.
Identified a single nucleotide substitution distinguishing HLA-A*02:1295N from HLA-A*02:02:01:01.

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Implication

Sequencing identifies a single nucleotide substitution in the HLA-A*02:1295N allele, enriching genetic diversity.

Abstract

HLA-A*02:1295N differs from HLA-A*02:02:01:01 by one nucleotide substitution in codon 157 in exon 3.

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Cite This Study

Pajot et al. (2026) studied this question.

synapsesocial.com/papers/6a4755e85c29257aa257ab9f https://doi.org/10.1111/tan.70808

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Synapse has enriched 8 closely related papers on similar clinical questions. Consider them for comparative context:

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4Characterisation of the Novel <i>HLA‐DPA1*02:02:19</i> Allele by Sequencing‐Based TypingOriginal Research · 2026 · 2 citations
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6Identification of the Novel <i>HLA‐A*02:540:02N</i> Allele by Next‐Generation Sequencing2025 · 2 citations
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8Extended Characterisation of the Coding Sequence of the <i>HLA‐A*02:97:01</i> Allele by Next and Third‐Generation SequencingOriginal Research · 2026 · 1 citations

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