Why the study?
It was unknown whether the presence of an arrhythmia or conduction disease is associated with mortality and heart failure hospitalizations in patients with ATTR-CM and the V142I mutation.
Is the presence of arrhythmia or conduction disease associated with higher rates of heart failure hospitalizations and mortality in patients with ATTR-CM and V142I mutation?
Population
111 patients with ATTR-CM and V142I mutation
Comparison
Presence vs absence of atrial arrhythmia, ventricular arrhythmia, or conduction disease
Design
Retrospective chart review
Follow-up
2 years
Key result
In patients with ATTR-CM and V142I mutation, atrial arrhythmia and conduction disease were associated with higher rates of heart failure hospitalization within 2 years (p=0.0011 and p=0.044).
Authors
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May warrant closer HF surveillance in V142I ATTR-CM with arrhythmias; leaves open whether rhythm interventions alter outcomes.
Cohort (n=111)
No
Is the presence of arrhythmia or conduction disease associated with higher rates of heart failure hospitalizations and mortality in patients with ATTR-CM and V142I mutation?
p-value: p=0.0011
In patients with ATTR-CM and the V142I mutation, atrial arrhythmias and conduction disease are significant risk factors for heart failure hospitalization within 2 years, though not for mortality.
Rim et al. (2022) conducted a cohort in ATTR-CM with V142I mutation (n=111). Atrial arrhythmia and conduction disease vs. Patients without atrial arrhythmia or conduction disease was evaluated on First heart failure hospitalization (HFH) within 2 years (p=0.0011). In patients with ATTR-CM and V142I mutation, atrial arrhythmia and conduction disease were associated with higher rates of heart failure hospitalization within 2 years (p=0.0011 and p=0.044).
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