Why the study?
ATTR wild-type cardiomyopathy is likely more common than appreciated, but data comparing mortality from ATTRwt-CM against other heart failure aetiologies were lacking.
Does ATTRwt amyloid cardiomyopathy increase long-term mortality compared to other heart failure aetiologies in patients with heart failure?
Population
2251 patients with heart failure across various cardiomyopathies
Comparison
ATTRwt-CM vs AL-CM, dCMP, HCM, HHD, and VHD
Design
Retrospective, observational, cohort study with prospectively collected data
Follow-up
Median 7.1 years
Authors
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ATTRwt-CM was associated with higher mortality than most HF aetiologies; leaves open whether early diagnosis or targeted therapy alters outcomes.
Does ATTRwt amyloid cardiomyopathy increase long-term mortality compared to other heart failure aetiologies in patients with heart failure?
ATTRwt amyloid cardiomyopathy is associated with significantly higher long-term mortality compared to other common causes of heart failure such as dilated, hypertrophic, and hypertensive cardiomyopathies.
Kocher et al. (2020) studied this question.
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