Key result
Once-daily bisoprolol (5-20 mg) significantly reduced diastolic blood pressure by 6.3 to 10.1 mmHg compared to 1.6 mmHg with placebo (p<0.01).
Why the study?
Does once-daily bisoprolol reduce blood pressure in patients with mild to moderate hypertension?
Population
240 patients with mild to moderate hypertension
Comparison
Bisoprolol 5, 10, or 20 mg once daily for 4 weeks vs Placebo
Design
RCT, randomized, double-blind, placebo-controlled
Follow-up
4 weeks
Authors
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Supports once-daily bisoprolol for BP control in mild-moderate hypertension; confirms randomized efficacy of beta-blockers.
RCT (n=240)
Double-blind
randomized
Does once-daily bisoprolol reduce blood pressure in patients with mild to moderate hypertension?
p-value: p=< 0.01
Once-daily bisoprolol at doses of 5-20 mg provides effective and safe 24-hour blood pressure control in patients with mild to moderate hypertension.
Davidov et al. (1994) conducted an RCT in mild to moderate hypertension (n=240). Bisoprolol vs. Placebo was evaluated on Mean reduction from baseline diastolic blood pressure at 24 h postdose (p=< 0.01). Once-daily bisoprolol (5-20 mg) significantly reduced diastolic blood pressure by 6.3 to 10.1 mmHg compared to 1.6 mmHg with placebo (p<0.01).
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