Why the study?
Does bisoprolol 20 mg once daily reduce blood pressure without reducing ejection fraction in patients with mild-to-moderate essential hypertension?
Population
26 patients with mild-to-moderate essential hypertension
Comparison
Bisoprolol 20 mg once daily vs Placebo
Design
RCT, randomized two-way crossover, double-blind, placebo-controlled
Follow-up
6 weeks
Authors
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Supports once-daily bisoprolol 20 mg in mild hypertension; extends RCT evidence for LVEF preservation.
Does bisoprolol 20 mg once daily reduce blood pressure without reducing ejection fraction in patients with mild-to-moderate essential hypertension?
Bisoprolol 20 mg daily effectively lowers blood pressure and heart rate in mild-to-moderate hypertension without compromising left ventricular ejection fraction.
Prisant et al. (1990) studied this question.
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