Why the study?
Does low-dose bisoprolol reduce morning home blood pressure and heart rate in patients with essential hypertension?
Does low-dose bisoprolol reduce morning home blood pressure and heart rate in patients with essential hypertension?
Low-dose bisoprolol (2.5/5 mg) significantly and rapidly decreases home blood pressure and heart rate in patients with essential hypertension.
Low-dose bisoprolol may aid home BP and HR control in essential hypertension; leaves open need for randomized confirmation before practice change.
We investigated morning home blood pressure (BP)- and heart rate (HR)-lowering effects of 2.5/5 mg bisoprolol in 70 patients with essential hypertension. After 4 weeks of treatment, mean home systolic/diastolic BP and HR significantly decreased by 2.6/5.2 mm Hg and by 8.1 bpm, respectively (all P < .05). The time required to reach 95% of the maximum lowering effect of bisoprolol (stabilizing time) was 5.1 days for home systolic BP (P = .2), 5.1 days for home diastolic BP (P = .0007), and 4.3 days for home HR (P < .0001). We demonstrated that the administration of low-dose bisoprolol significantly and rapidly decreased home BP and HR.
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Satoh et al. (2012) studied this question.
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