Key result
Internal dialysis of 10 micromol/L PIP2 increased HERG K+ current amplitude, shifted voltage-dependence of activation in a hyperpolarizing direction, and attenuated channel run-down.
Population
Cells expressing HERG K(+) channels (and coexpressing alpha1A-receptor in some experiments)
Comparison
Internal dialysis or application of PIP2… vs Control conditions
Design
Preclinical
Authors
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Animal data link PIP2 to HERG modulation; leaves open translation to human autonomic control of excitability or arrhythmia risk.
Dynamic regulation of HERG K+ channels is achieved via receptor-mediated changes in PIP2 concentrations, providing a potential mechanism for autonomic control of myocardial excitability.
Bian et al. (2001) studied this question. Phosphatidyl inositol 4,5-bisphosphate (PIP2) was evaluated on HERG K+ channel activity (current amplitude and gating kinetics). Internal dialysis of 10 micromol/L PIP2 increased HERG K+ current amplitude, shifted voltage-dependence of activation in a hyperpolarizing direction, and attenuated channel run-down.
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