Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
February 3, 1998Proceedings of the National Academy of SciencesOpen Access

Activation of the atrial K ACh channel by the βγ subunits of G proteins or intracellular Na + ions depends on the presence of phosphatidylinositol phosphates

View Full Paper
Ask AI
Bookmark
Share

Population

Preclinical model (cardiac muscarinic K+ channels / KACh)

Comparison

Phosphatidylinositol 4,5-bisphosphate… vs Control conditions (absence of PIP2 or ATP)

Design

Preclinical

Authors

JSJin SuiChinese Academy of SciencesJPJérôme Petit-JacquesNew York UniversityDLDiomedes E. LogothetisBoston University

Discussion

Loading...

Member takes

Overview

PIP2 dependence of KACh channels in animal models is hypothesis-generating; leaves open relevance to human cardiac electrophysiology.

Structured PICO

P
Population
Preclinical model (cardiac muscarinic K+ channels / KACh)
I
Intervention
Phosphatidylinositol 4,5-bisphosphate (PIP2) application, depletion, or block
C
Comparator
Control conditions (absence of PIP2 or ATP)
O
Outcome
KACh channel activity and its response to Gbetagamma subunits or intracellular Na+ ionssurrogate

Regulation of cardiac KACh channel activity by Gbetagamma subunits or Na+ ions is crucially dependent on PIP2, highlighting phosphatidylinositol phospholipids as a key control point in signal transduction.

Cite This Study

Sui et al. (1998) studied this question.

synapsesocial.com/papers/6a7db2c810b6f5f3737d8bc3https://doi.org/10.1073/pnas.95.3.1307
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Regulation of Cardiac Na + ,Ca 2+ Exchange and K ATP Potassium Channels by PIP 21996 · 678 citations
  2. 2Na+ activation of the muscarinic K+ channel by a G-protein-independent mechanism.1996 · 129 citations
  3. 3Gβγ Binds Directly to the G Protein-gated K+ Channel, IKACh1995 · 236 citations
  4. 4Anionic Phospholipids Activate ATP-sensitive Potassium Channels1997 · 329 citations
  5. 5CYTOPLASMIC ATP-DEPENDENT REGULATION OF ION TRANSPORTERS AND CHANNELS: Mechanisms and Messengers1997 · 167 citations