Key result
Left ventricular global longitudinal strain (HR 0.87 per 1%; P=0.03) and mitral annular plane systolic excursion (HR 0.84 per 1 mm; P=0.03) predicted sudden cardiac death and ventricular arrhythmia.
Why the study?
Does echocardiographic assessment of left ventricular longitudinal function predict sudden cardiac death or life-threatening ventricular arrhythmia in adults with repaired tetralogy of Fallot?
Cohort (n=413)
Does echocardiographic assessment of left ventricular longitudinal function predict sudden cardiac death or life-threatening ventricular arrhythmia in adults with repaired tetralogy of Fallot?
Hazard Ratio: 0.87
p-value: p=0.03
Left ventricular longitudinal dysfunction, assessed by routine echocardiography, is an independent predictor of sudden cardiac death and life-threatening ventricular arrhythmias in adults with repaired tetralogy of Fallot.
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Longitudinal LV function was associated with sudden death risk in repaired tetralogy of Fallot; leaves open incremental value for risk stratification.
Diller et al. (2012) conducted a cohort in Repaired tetralogy of Fallot (n=413). Left ventricular longitudinal dysfunction was evaluated on Composite of sudden cardiac death or life-threatening ventricular arrhythmia (sustained ventricular tachycardia, resuscitated sudden cardiac death, or appropriate ICD discharge) (HR 0.87, p=0.03). Left ventricular global longitudinal strain (HR 0.87 per 1%; P=0.03) and mitral annular plane systolic excursion (HR 0.84 per 1 mm; P=0.03) predicted sudden cardiac death and ventricular arrhythmia.
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