Why the study?
Despite significant cardiovascular mortality after tetralogy of Fallot repair, data on the risk and prognostic implications of left ventricular cardiomyopathy were limited.
Does left ventricular systolic dysfunction increase the risk of cardiovascular events in adult patients after tetralogy of Fallot repair?
Population
574 adult patients after TOF repair with echocardiographic LVEF assessment
Comparison
Left ventricular systolic dysfunction vs preserved LVEF
Design
Cohort study
Follow-up
10.5 ± 6.2 years
Key result
A 5%-point decrease in left ventricular ejection fraction was an independent predictor of mortality (HR 1.16; 95% CI 1.16-1.24; P=0.003) in adults after tetralogy of Fallot repair.
Authors
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May warrant closer LVEF monitoring in adult TOF survivors; leaves open whether LV-targeted therapy alters mortality.
Cohort (n=574)
Does left ventricular systolic dysfunction increase the risk of cardiovascular events in adult patients after tetralogy of Fallot repair?
Hazard Ratio: 1.16 (95% CI 1.16–1.24)
p-value: p=0.003
Left ventricular systolic dysfunction is present in a significant minority of adults after TOF repair and is independently associated with increased cardiovascular mortality and events.
Egbe et al. (2019) conducted a cohort in Tetralogy of Fallot (TOF) repair (n=574). Left ventricular systolic dysfunction (LVD) / LVEF decrease vs. Preserved LVEF was evaluated on Mortality (HR 1.16, 95% CI 1.16-1.24, p=0.003). A 5%-point decrease in left ventricular ejection fraction was an independent predictor of mortality (HR 1.16; 95% CI 1.16-1.24; P=0.003) in adults after tetralogy of Fallot repair.