Key result
TOF repair after age 2 is linked to markedly depressed LV work-function during afterload stress.
Why the study?
Does surgical repair of tetralogy of Fallot before 2 years of age preserve left ventricular function under afterload stress compared to repair after 2 years of age?
Population
27 patients, including 20 postoperative tetralogy of Fallot patients without significant residual shunts or…
Comparison
Surgical repair of tetralogy of Fallot before 2… vs Surgical repair of tetralogy of Fallot after 2…
Design
Cohort
Authors
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Supports early TOF repair to preserve LV reserve under stress; hypothesis-generating and requires prospective confirmation.
Observational (n=27)
Does surgical repair of tetralogy of Fallot before 2 years of age preserve left ventricular function under afterload stress compared to repair after 2 years of age?
Absolute Event Rate: 0.21% vs 0.89%
p-value: p=<0.001
Early definitive repair of tetralogy of Fallot before 2 years of age preserves left ventricular function under afterload stress, whereas later repair is associated with unmasked LV dysfunction.
Borow et al. (1980) conducted an observational in Tetralogy of Fallot (n=27). Tetralogy of Fallot repair after 2 years of age vs. Tetralogy of Fallot repair before 2 years of age was evaluated on Slope (m) for LV end-diastolic pressure vs LV minute-work index relationship during afterload stress (p=<0.001). Tetralogy of Fallot repair after age 2 was associated with depressed LV work-function curve slopes during afterload stress compared to repair before age 2 (0.21 vs 0.89, p<0.001).
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