Key result
CaMK2 inhibition reduced both MyBP-C and TnI phosphorylation and decreased active force, reducing the normalized change in force per change in calcium by 19-39% in mouse papillary bundles.
Population
Intact mouse papillary bundles
Comparison
Inhibition of MyBP-C and TnI phosphorylation… vs Before inhibition (baseline measurements)
Design
Preclinical
Authors
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This in vitro method isolates myofibrillar function from calcium handling in FFR; leaves open validation in intact hearts and clinical translation.
Effect estimate: 19-39% reduction
Phosphorylation of MyBP-C and TnI contributes significantly to the rates of cardiac force development and relaxation in mouse models.
Tong et al. (2004) studied Mouse cardiac muscle twitch dynamics. CaMK2 inhibitor (autocamtide-2 related inhibitory peptide) or PKA inhibitor (14-22 amide) vs. Before inhibition (baseline) was evaluated on Normalized change in force per change in calcium (19-39% reduction). CaMK2 inhibition reduced both MyBP-C and TnI phosphorylation and decreased active force, reducing the normalized change in force per change in calcium by 19-39% in mouse papillary bundles.
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