Key result
Modulation of mammalian heart muscle contractile proteins via cAMP-sensitive phosphorylation of troponin I increases the calcium activation threshold up to 5-fold without changing maximum force.
Population
Mammalian heart muscle
Design
Review
Authors
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Supports troponin I phosphorylation in tuning calcium sensitivity; leaves open therapeutic targeting in heart failure.
Cardiac contractility is regulated by complex phosphorylation pathways of contractile proteins in response to autonomic stimulation.
Saul Winegrad (1984) conducted a review in Mammalian heart muscle physiology. Modulation of mammalian heart muscle contractile proteins via cAMP-sensitive phosphorylation of troponin I increases the calcium activation threshold up to 5-fold without changing maximum force.
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