Heart rate is associated with progression of atrial fibrillation, independent of rhythm
Key result
Lower heart rate was associated with a decreased likelihood of atrial fibrillation progression (OR 0.84; 95% CI 0.79-0.89; p<0.0001 per 10 bpm decrease ≤80).
Population
6,235 patients with paroxysmal or persistent atrial fibrillation at baseline from the Outcomes Registry for…
Design
Cohort
Follow-up
median 18 (IQR 12-24) months
Authors
Discussion
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Implication
Should not yet change rate-control targets in AF; hypothesis-generating and requires randomized confirmation.
Study Design
Type
Cohort (n=6,235)
Structured PICO
P
Population
6,235 patients with paroxysmal or persistent atrial fibrillation at baseline, followed for a median of 18 months.
O
Outcome
Progression of atrial fibrillation to a more sustained form
Main Result
Odds Ratio: 0.84 (95% CI 0.79–0.89)
p-value: p=<0.0001
Higher heart rate, older age, and AF on baseline ECG are strong independent predictors of progression to more sustained forms of atrial fibrillation in patients with paroxysmal or persistent AF.
Cite This Study
Holmqvist et al. (2015) conducted a cohort in Paroxysmal or persistent atrial fibrillation (n=6,235). Lower heart rate vs. Higher heart rate was evaluated on Atrial fibrillation progression (OR 0.84, 95% CI 0.79 to 0.89, p=<0.0001). Lower heart rate was associated with a decreased likelihood of atrial fibrillation progression (OR 0.84; 95% CI 0.79-0.89; p<0.0001 per 10 bpm decrease ≤80).