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This study aims to assess the real-world effectiveness of respiratory syncytial virus (RSV) vaccination in preventing infections among adults aged 50 and older.

July 5, 2026BMC Infectious DiseasesOpen Access

Preventive effectiveness of respiratory syncytial virus vaccination in older adults: a multi-institutional cohort study

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This study aims to assess the real-world effectiveness of respiratory syncytial virus (RSV) vaccination in preventing infections among adults aged 50 and older.
Multi-institutional cohort study using data from the TriNetX Research Network
Included individuals aged ≥ 50 years from January 1, 2023, to May 31, 2026
Analyzed 179,871 matched patients using Cox proportional-hazards models to estimate hazard ratios for RSV infection
Vaccinated group had an incidence rate of 0.17 per 100 person-years for RSV infection, compared to 0.27 in the unvaccinated group (HR, 0.65; 95% CI, 0.58–0.73)
Vaccinated individuals had an incidence rate of 0.12 per 100 person-years for RSV-associated lower respiratory tract disease, versus 0.19 in unvaccinated individuals (HR, 0.69; 95% CI, 0.60–0.79)
Risk reductions were consistent across various subgroups based on age, sex, and comorbidity

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Implication

Cohort study evaluates RSV vaccination effectiveness in preventing infections among older adults, indicating significant protective benefits.

Cite This Study

Chao et al. (2026) studied this question.

synapsesocial.com/papers/6a49f648f5d1d45b28800d00 https://doi.org/10.1186/s12879-026-13920-4

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Implication

Cohort study evaluates RSV vaccination effectiveness in preventing infections among older adults, indicating significant protective benefits.

Preventive effectiveness of respiratory syncytial virus vaccination in older adults: a multi-institutional cohort study

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Discussion

Implication

Cite This Study

Preventive effectiveness of respiratory syncytial virus vaccination in older adults: a multi-institutional cohort study

Key Points

Discussion

Implication

Cite This Study

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