Key result
Direct injection of a plasmid vector expressing hIL-1Ra improved 14-day survival to 77% compared to 30% with empty vector (P<0.01) in mice with experimental coxsackieviral myocarditis.
Why the study?
Does direct injection of a plasmid vector expressing hIL-1Ra improve survival in a mouse model of coxsackieviral myocarditis?
Does direct injection of a plasmid vector expressing hIL-1Ra improve survival in a mouse model of coxsackieviral myocarditis?
Absolute Event Rate: 77% vs 30%
p-value: p=<0.01
Local expression of hIL-1Ra via plasmid DNA injection improves survival and reduces myocardial inflammation in a murine model of viral myocarditis.
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IL-1Ra gene therapy merits human translation studies in viral myocarditis; leaves open clinical efficacy and safety.
Lim et al. (2002) studied coxsackieviral (CVB3) myocarditis (n=50). plasmid vector expressing human IL-1 receptor antagonist (hIL-1Ra) vs. empty vector was evaluated on 14-day survival rate (p=<0.01). Direct injection of a plasmid vector expressing hIL-1Ra improved 14-day survival to 77% compared to 30% with empty vector (P<0.01) in mice with experimental coxsackieviral myocarditis.
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