Why the study?
Does central gene transfer of human IL-10 reduce hypothalamic inflammation and evidence of heart failure in rats after myocardial infarction?
Population
Sprague-Dawley rats undergoing coronary ligation to induce myocardial infarction (MI) or sham surgery.
Comparison
Adenoviral vectors encoding human interleukin-10… vs Adenoviral vectors encoding beta-galactosidase…
Design
Preclinical
Follow-up
1 week after injection
Authors
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Central IL-10 delivery may attenuate post-MI hypothalamic inflammation and HF progression in rats; hypothesis-generating and should not yet inform human therapy.
Does central gene transfer of human IL-10 reduce hypothalamic inflammation and evidence of heart failure in rats after myocardial infarction?
Central gene transfer of the anti-inflammatory cytokine IL-10 into the brain ameliorates hypothalamic inflammation and signs of heart failure in a rat model of myocardial infarction.
Yu et al. (2007) studied this question.
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