Key result
Murine IL-10 gene transfer by electroporation increased the 21-day survival rate to 100% compared to 60% in control rats with experimental autoimmune myocarditis.
Why the study?
Does gene transfer of murine IL-10 by electroporation improve survival and attenuate myocardial lesions in a rat model of experimental autoimmune myocarditis?
Population
Nine-week-old Lewis rats with experimental autoimmune myocarditis induced by pig myosin inoculation, n=30
Comparison
Plasmid vector expressing murine IL-10 cDNA… vs Empty plasmid
Design
Preclinical
Follow-up
21 days
Authors
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IL-10 gene transfer merits further preclinical study in myocarditis; leaves open translation to human disease.
Does gene transfer of murine IL-10 by electroporation improve survival and attenuate myocardial lesions in a rat model of experimental autoimmune myocarditis?
Absolute Event Rate: 100% vs 60%
Gene transfer of IL-10 by electroporation significantly improves survival and attenuates myocardial lesions in a rat model of autoimmune myocarditis.
Watanabe et al. (2001) studied Experimental autoimmune myocarditis (n=30). Murine IL-10 (mIL-10) gene transfer by electroporation vs. Empty plasmid was evaluated on 21-day survival rate. Murine IL-10 gene transfer by electroporation increased the 21-day survival rate to 100% compared to 60% in control rats with experimental autoimmune myocarditis.
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