Key result
A 72-year-old woman developed mitral transcatheter heart valve thrombosis after TMVR, prompting a literature review of 1,484 patients to discuss thromboprophylaxis and treatment strategies.
Why the study?
Experience with TMVR is new, with much remaining to discover regarding durability, long-term outcomes, and complications such as mitral THV thrombosis.
Case Report (n=1,485)
Mitral transcatheter heart valve thrombosis is a notable complication following TMVR, necessitating careful consideration of thromboprophylaxis and management strategies.
Answers are grounded in this paper and cite their sources.
Clinicians should monitor for mitral THV thrombosis after TMVR; this case leaves open questions on incidence and prevention.
Transcatheter mitral valve replacement (TMVR) is an exciting alternative therapy for complex patients with mitral valve disease. Experience with TMVR is new and there is a lot yet to discover about their durability, long-term outcomes, and complications including mitral transcatheter heart valve (THV) thrombosis. Many factors have been speculated to increased risk of THV thrombosis. Here, we report a case of a 72-year-old woman who developed mitral THV thrombosis after undergoing TMVR for severe mitral regurgitation with mitral annular calcification. We reviewed 42 TMVR papers with 1,484 patients, including 60 with mitral THV thrombosis. We discussed the most common strategies used for mitral THV thromboprophylaxis and treatment.
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Alarfaj et al. (2020) conducted a case report in Mitral valve disease and transcatheter heart valve thrombosis (n=1,485). Transcatheter mitral valve replacement (TMVR) was evaluated on Mitral THV thrombosis. A 72-year-old woman developed mitral transcatheter heart valve thrombosis after TMVR, prompting a literature review of 1,484 patients to discuss thromboprophylaxis and treatment strategies.
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