What is the clinical evidence from this study?

Study design: Cross-Sectional. Population: Healthy adults free of hypertension and cardiovascular disease (n=142). Intervention: Male gender vs. Female gender. Primary outcome: Left ventricular volumetric (EDV, ESV, mass) and unidimensional measures (p=<0.001).

What does this research mean for the field?

Left ventricular volumetric and unidimensional measures on cardiovascular magnetic resonance are significantly greater in men than in women, with volumetric differences persisting after body surface area adjustment, whereas ejection fraction does not differ by gender. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To derive gender-specific reference values for left ventricular anatomy and function using cardiovascular magnetic resonance imaging in a healthy adult population.

July 6, 2026Journal of the American College of Cardiology

Gender differences and normal left ventricular anatomy in an adult population free of hypertension

Q: What are the key findings of this study?

Male gender was associated with significantly greater left ventricular volumetric and unidimensional measures compared to women (P<0.001), which persisted for volumes after body surface area adjustment.

Q: What does this research mean for the field?

Left ventricular volumetric and unidimensional measures on cardiovascular magnetic resonance are significantly greater in men than in women, with volumetric differences persisting after body surface area adjustment, whereas ejection fraction does not differ by gender. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

Q: What question did this study set out to answer?

To derive gender-specific reference values for left ventricular anatomy and function using cardiovascular magnetic resonance imaging in a healthy adult population.

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Key result

Male gender is linked to greater LV volumes and dimensions than women despite BSA adjustment.

P<0.001
n=142

Why the study?

Cardiovascular magnetic resonance imaging is increasingly applied clinically, but age-relevant, gender-specific normative values for left ventricular anatomy and function were unavailable.

Population

142 Framingham Heart Study Offspring participants free of overt cardiovascular disease and hypertension

Comparison

Men vs women

Design

Cross-sectional population-based study

Authors

CSCarol J SaltonCardiac Imaging MCMichael L. ChuangCardiac Imaging COChristopher J. O’DonnellPreventive Cardiology

Discussion

Member takes

Implication

Sex-specific CMR reference values may refine LV assessment; leaves open validation in broader populations before clinical adoption.

Key Points

To derive gender-specific reference values for left ventricular anatomy and function using cardiovascular magnetic resonance imaging in a healthy adult population.
Analyzed CMR data from 318 Framingham Heart Study participants free of cardiovascular disease.
Excluded subjects with clinical hypertension, resulting in 142 subjects (63 men, 79 women).
Assessed left ventricular end-diastolic volume, end-systolic volume, mass, ejection fraction, and linear dimensions.
Men showed significantly greater EDV, ESV, and mass than women (p < 0.001).
After adjusting for body surface area, men exhibited larger volumetric measures (p < 0.001), while women had greater end-diastolic dimension indexed to BSA (p < 0.001).
Global LVEF was similar between genders (men = 0.69; women = 0.70).

Study Design

Type

Cross-Sectional (n=142)

PICO

Population

142 healthy adults (mean age 57 years, 56% female) free of cardiovascular disease and hypertension, evaluated to derive gender-specific cardiovascular magnetic resonance reference values.

Exposure / Comparator

Male gender vs Female gender

Primary Outcome

Left ventricular volumetric (EDV, ESV, mass) and unidimensional measures, p=<0.001

Main Result

p-value: p=<0.001

Cite This Study

Salton et al. (2002) conducted a cross-sectional in Healthy adults free of hypertension and cardiovascular disease (n=142). Male gender vs. Female gender was evaluated on Left ventricular volumetric (EDV, ESV, mass) and unidimensional measures (p=<0.001). Male gender was associated with significantly greater left ventricular volumetric and unidimensional measures compared to women (P<0.001), which persisted for volumes after body surface area adjustment.

synapsesocial.com/papers/6a4b730ef318da06943cd5e9 https://doi.org/10.1016/s0735-1097(02)01712-6

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Gender differences and normal left ventricular anatomy in an adult population free of hypertension

Discussion

Member takes

Implication

Key Points

Study Design

PICO

Main Result

Cite This Study

Gender differences and normal left ventricular anatomy in an adult population free of hypertension

Discussion

Member takes

Implication

Key Points

Study Design

PICO

Main Result

Cite This Study

Also Consider

Also Consider