Key result
Prolonged QTc interval was independently associated with an increased risk of all-cause mortality (HR 2.56; P=0.008) in patients with low-flow low-gradient aortic stenosis and reduced LVEF.
Why the study?
Does prolonged QTc predict mortality in patients with low-flow low-gradient aortic stenosis and reduced LVEF?
Population
93 patients with low-flow, low-gradient aortic stenosis and reduced LVEF, mean age 73±10 years, 74% men.
Comparison
Prolonged QTc vs Normal QTc
Design
Cohort
Follow-up
median 2.0 years
Authors
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Prolonged QTc was associated with worse LV function and outcomes in LF-LG AS; hypothesis-generating for risk stratification.
Cohort (n=93)
Does prolonged QTc predict mortality in patients with low-flow low-gradient aortic stenosis and reduced LVEF?
Hazard Ratio: 2.56
p-value: p=0.008
Prolonged QTc is an independent predictor of all-cause and cardiovascular mortality in patients with low-flow, low-gradient aortic stenosis and reduced LVEF, offering a simple tool for risk stratification.
Dahou et al. (2016) conducted a cohort in Low-flow low-gradient aortic stenosis with low left ventricular ejection fraction (n=93). Prolonged QTc interval vs. Normal QTc interval was evaluated on All-cause mortality (HR 2.56, p=0.008). Prolonged QTc interval was independently associated with an increased risk of all-cause mortality (HR 2.56; P=0.008) in patients with low-flow low-gradient aortic stenosis and reduced LVEF.
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