Key result
Higher levels of Angiopoietin-2 were inversely correlated with global longitudinal strain (r = -0.374, p = 0.001) in hemodialysis patients with normal left ventricular ejection fraction.
Why the study?
The study evaluated the association between endothelium-related biomarkers and cardiac remodeling in hemodialysis patients, and how high blood pressure and diabetes mellitus modulate these associations.
Is Angiopoietin-2 associated with functional cardiac remodeling in hemodialysis patients with normal left ventricular ejection fraction?
Comparison
Endothelium-related biomarkers correlated with echocardiographic indices
Design
Cross-sectional study
Authors
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AGPT2 may mark subclinical strain impairment in hemodialysis; hypothesis-generating and should not yet change practice.
Cross-Sectional (n=71)
Is Angiopoietin-2 associated with functional cardiac remodeling in hemodialysis patients with normal left ventricular ejection fraction?
Effect estimate: r = -0.374
p-value: p=0.001
Higher levels of Angiopoietin-2 are associated with worse subclinical cardiac function (lower global longitudinal strain) in hemodialysis patients, an effect moderated by blood pressure and diabetes.
Oliveira et al. (2022) conducted a cross-sectional in Hemodialysis with normal left ventricular ejection fraction (n=71). Angiopoietin-2 (AGPT2) was evaluated on Global longitudinal strain (r = -0.374, p=0.001). Higher levels of Angiopoietin-2 were inversely correlated with global longitudinal strain (r = -0.374, p = 0.001) in hemodialysis patients with normal left ventricular ejection fraction.
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