Key result
Coexisting HF and CKD links to ~52% 5-year mortality, while HF and T2D predicts new comorbidities.
Why the study?
Heart failure, type 2 diabetes, and chronic kidney disease commonly coexist, but the characteristics, prognosis, and healthcare utilisation of individuals with two of these conditions needed evaluation.
Population
Individuals in England diagnosed with two of HF, T2D, or CKD (64 226 CKD+HF, 82 431 CKD+T2D, 13 872 HF+T2D)
Comparison
CKD and HF vs CKD and T2D vs HF and T2D cohorts
Design
Retrospective population-based linked electronic health records study
Follow-up
5 years
Authors
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HF-CKD multimorbidity signals highest burden; leaves open prospective studies before guiding integrated care.
Cohort (n=160,529)
Yes
The combination of heart failure and chronic kidney disease carries the highest mortality and healthcare burden among pairs of HF, CKD, and T2D.
Pasea et al. (2023) conducted a cohort in Multimorbidity (Heart failure, chronic kidney disease, type 2 diabetes) (n=160,529). Coexistence of two conditions (HF, T2D, or CKD) vs. Other disease pairs was evaluated on Incidence of the third condition and all-cause mortality at 5 years. Coexistence of HF and CKD was associated with the highest 5-year all-cause mortality (51.6%), whereas HF and T2D had the highest 5-year incidence of developing a third condition (37.0%).
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