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Revisiting the Carbon Footprint of Single‐Use Technologies in Biomanufacturing: A Bottom‐Up Analysis Reveals a Paradigm Shift

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This analysis aims to reassess the carbon footprint of single-use technologies in biopharmaceutical manufacturing.
Conducted a bottom-up analysis of the CO2 footprint at a 2000 L scale.
Utilized two real-world facility case studies: a full-single-use and a hybrid-single-use model.
Performed a detailed evaluation of operational efficiencies and emissions.
The CO2 footprint of single-use technologies was found to be significantly higher than previously estimated.
Key emission hotspots identified included filters and bags in the single-use systems.
Hybrid facilities combining single-use and stainless-steel systems showed potential for reduced plastic waste and emissions.

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Highlights the increased carbon emissions from single-use technologies in biomanufacturing, suggesting a shift in sustainability strategies.

Reiners et al. (2026) studied this question.

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Highlights the increased carbon emissions from single-use technologies in biomanufacturing, suggesting a shift in sustainability strategies.