What question did this study set out to answer?

To evaluate the role of single-use technologies and sustainability by design approaches in enhancing the environmental performance of modern biopharmaceutical manufacturing.

August 15, 2026Applied Microbiology and BiotechnologyOpen Access

Single-use technologies and sustainability by design in biopharma production

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Authors

MOMelanie OttingerThermo Fisher Scientific (United Kingdom)IWIrina WenkThermo Fisher Scientific (United Kingdom)BBBéla BrühlmannZHAW Zurich University of Applied Sciences

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Implication

Review reveals environmental trade-offs and implementation gaps for single-use biomanufacturing, highlighting early life-cycle assessment and design integration.

Key Points

To evaluate the role of single-use technologies and sustainability by design approaches in enhancing the environmental performance of modern biopharmaceutical manufacturing.
Reviewed recent advances in environmental assessment tools, life cycle assessments, process engineering, and digital bioprocessing technologies.
Evaluated industry stakeholder survey data regarding sustainability awareness, governance structures, and implementation barriers across the biopharma value chain.
Single-use technologies reduce water and energy consumption and improve facility turnaround relative to stainless steel systems, but generate significant plastic waste and end-of-life disposal challenges.
Industry stakeholders demonstrate increasing sustainability awareness but face persistent gaps in governance, technical knowledge, and practical implementation across supply chains.
Early integration of life cycle assessment metrics alongside process intensification, continuous processing, and process analytical technologies substantially lowers overall environmental impact.

Cite This Study

Ottinger et al. (2026) studied this question.

synapsesocial.com/papers/6a80199875c2e31742c858be https://doi.org/10.1007/s00253-026-13930-x

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Implication

Review reveals environmental trade-offs and implementation gaps for single-use biomanufacturing, highlighting early life-cycle assessment and design integration.

Single-use technologies and sustainability by design in biopharma production

Discussion

Member takes

Implication

Key Points

Cite This Study

Single-use technologies and sustainability by design in biopharma production

Discussion

Member takes

Implication

Key Points

Cite This Study

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