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June 29, 2009Cell Motility and the Cytoskeleton

Human angiomotin‐like 1 associates with an angiomotin protein complex through its coiled‐coil domain and induces the remodeling of the actin cytoskeleton

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Authors

VGValérie GagnéInstitute for Research in Immunology and CancerJMJulie MoreauMonash UniversityMPMélodie B. PlourdeUniversité du Québec à Trois-Rivières

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Overview

Randomized trial assesses angiomotin-like 1's impact on actin remodeling in endothelial cells, suggesting implications for angiogenesis-driven diseases.

Key Points

  • This study investigates the role of angiomotin-like 1 in associating with p80-angiomotin and its effects on the actin cytoskeleton.
  • Structure-function studies were conducted to examine the interaction between angiomotin-like 1 and p80-angiomotin.
  • Immunofluorescence studies were performed to analyze the localization of angiomotin-like 1 with actin filaments.
  • Migration assays were conducted to measure changes in endothelial cell movement after angiomotin-like 1 modulation.
  • Angiomotin-like 1 associates with the p80-angiomotin complex through its coiled-coil domain.
  • Angiomotin-like 1 co-localizes with filamentous actin and remodels the actin cytoskeleton.
  • Increased migration velocity and decreased directionality were observed with angiomotin-like 1 overexpression.

Cite This Study

Gagné et al. (2009) studied this question.

synapsesocial.com/papers/6a4d1feb38a87fdfae022e2ahttps://doi.org/10.1002/cm.20405
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