Key result
Carvedilol and metoprolol attenuated cardiac remodeling and apoptosis in pacing-induced heart failure, with oxidative stress correlating with fractional shortening changes (r=0.706, P<0.0001).
Why the study?
Do carvedilol and metoprolol attenuate ventricular remodeling, oxidative stress, and apoptosis in a rabbit model of pacing-induced heart failure?
RCT
randomized
Do carvedilol and metoprolol attenuate ventricular remodeling, oxidative stress, and apoptosis in a rabbit model of pacing-induced heart failure?
The antioxidant and antiapoptotic actions of carvedilol and metoprolol appear to be important mechanisms for their beneficial effects in heart failure.
No takes yet. Share an insight, caveat, or question.
Findings remain preclinical; leaves open whether antioxidant effects of carvedilol or metoprolol translate to human HF outcomes.
Kawai et al. (2004) conducted an RCT in congestive heart failure (CHF). carvedilol, metoprolol, or propranolol plus doxazosin vs. placebo pellets was evaluated on cardiac ventricular remodeling, cardiac hypertrophy, oxidative stress, and myocyte apoptosis. Carvedilol and metoprolol attenuated cardiac remodeling and apoptosis in pacing-induced heart failure, with oxidative stress correlating with fractional shortening changes (r=0.706, P<0.0001).
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